Dose determination of fondaparinux in healthy cats
Nonya N Fiakpui, Daniel E Hogan, Ted Whittem, Henry W Green, Eryn A Shipley, Kimberly A Sederquist
American Journal of Veterinary Research | AMER VETERINARY MEDICAL ASSOC | Published : 2012
OBJECTIVE: To establish practical doses and administration frequencies of fondaparinux for cats that would approximate human therapeutic peak and trough plasma anti-factor Xa activities for thromboprophylaxis (TP) and thrombosis treatment (TT) protocols. ANIMALS: 6 healthy adult purpose-bred cats. PROCEDURES: Dosage protocols for TP and TT were selected on the basis of a single compartment pharmacokinetic model incorporating data from humans but modified to account for the higher body weight-normalized cardiac output of cats. Fondaparinux was administered at 0.06 mg/kg, SC, every 12 hours (TP) for 7 days in one session, and 0.20 mg/kg, SC, every 12 hours (TT) for 7 days in another, with a mi..View full abstract
Supported by the American College of Veterinary Internal Medicine Cardiology Research Committee.