Nanoporous Peptide Particles for Encapsulating and Releasing Neurotrophic Factors in an Animal Model of Neurodegeneration
Justin Tan, Yajun Wang, Xiaopei Yip, Fergal Glynn, Robert K Shepherd, Frank Caruso
ADVANCED MATERIALS | WILEY-V C H VERLAG GMBH | Published : 2012
Neurotrophin-BDNF can be effectively encapsulated in nanoporous poly(L-glutamic acid) particles prepared via mesoporous silica templating. The loaded BDNF can be released in a sustained manner with retained biological activity. Animal experiments demonstrate the released BDNF can efficiently rescue the auditory neurons (as indicated by the arrows) in the cochlea of guinea pigs with sensorineural hearing loss.
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Awarded by National Health and Medical Research Council (NHMRC)
Awarded by National Institutes of Health (USA)
This work was supported by the National Health and Medical Research Council (NHMRC) Project Grant APP1005071 (R.K.S., F.C., J.T., Y.W.), by the Australian Research Council under the Federation Fellowship scheme (F.C.), the Royal Victorian Eye and Ear Hospital (F.G.) and the National Institutes of Health (USA) HHS-N-263-2007-00053-C (R.K.S.). The Bionics Institute acknowledges the support it receives from the Victorian government through its Operational Infrastructure Support Program. We thank Genevieve Evin, Jacqueline Andrews, Dimitra Stathopoulos, and Alison Neil for advice and assistance.