Journal article
The effects of urethane on the isoflurane minimum alveolar concentration in rats
SH Bauquier, FJ Golder
Laboratory Animals | Published : 2010
Abstract
Urethane is often used as a sole anaesthetic agent for non-recovery studies in laboratory animals. However, the use of urethane is controversial, in part, because the electroencephalogram after urethane administration is similar to the electroencephalogram recorded from unanaesthetized animals. Here, we assessed the minimum alveolar concentration (MAC)-sparing effects of urethane by measuring the effect of two doses of urethane on the MAC of isoflurane in male Sprague Dawley rats. Isoflurane MAC was measured before and after intravenous administration of urethane at 1.0 g/kg (Group G1, n = 6) and 1.5 g/kg (Group G1.5, n = 6), or an equal volume of 0.9% saline (Group G s, n = 6). Baseline iso..
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Funding Acknowledgements
We extend our appreciation to Sharon Martinez for her technical assistance with the experiments and to Dr Daljit Vudathala who measured the serum and brainstem urethane concentrations. This work was supported by a grant provided by the Department of Clinical Studies-Philadelphia, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.