Increased Mast Cell Density and Airway Responses to Allergic and Non-Allergic Stimuli in a Sheep Model of Chronic Asthma
Joanne Van der Velden, Donna Barker, Garry Barcham, Emmanuel Koumoundouros, Kenneth Snibson
PLoS One | PUBLIC LIBRARY SCIENCE | Published : 2012
BACKGROUND: Increased mast cell (MC) density and changes in their distribution in airway tissues is thought to contribute significantly to the pathophysiology of asthma. However, the time sequence for these changes and how they impact small airway function in asthma is not fully understood. The aim of the current study was to characterise temporal changes in airway MC density and correlate these changes with functional airway responses in sheep chronically challenged with house dust mite (HDM) allergen. METHODOLOGY/PRINCIPAL FINDINGS: MC density was examined on lung tissue from four spatially separate lung segments of allergic sheep which received weekly challenges with HDM allergen for 0, 8..View full abstract
Awarded by National Health and Medical Research Council (NHMRC) of Australia
This work was funded by the National Health and Medical Research Council (NHMRC) of Australia (Grant no. 454437). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.