Cathepsin B Inhibition Limits Bone Metastasis in Breast Cancer

Nimali P Withana; Galia Blum; Mansoureh Sameni; Clare Slaney; Arulselvi Anbalagan; Mary B Olive; Bradley N Bidwell; Laura Edgington; Ling Wang; Kamiar Moin; Bonnie F Sloane; Robin L Anderson; Matthew S Bogyo; Belinda S Parker

Journal article

Cathepsin B Inhibition Limits Bone Metastasis in Breast Cancer

Nimali P Withana, Galia Blum, Mansoureh Sameni, Clare Slaney, Arulselvi Anbalagan, Mary B Olive, Bradley N Bidwell, Laura Edgington, Ling Wang, Kamiar Moin, Bonnie F Sloane, Robin L Anderson, Matthew S Bogyo, Belinda S Parker

CANCER RESEARCH | AMER ASSOC CANCER RESEARCH | Published : 2012

DOI: 10.1158/0008-5472.CAN-11-2759

University of Melbourne Researchers

Laura Edgington-Mitchell Author Biochemistry and Molecular Biology

Clare Slaney Author The Sir Peter MacCallum Department of Oncology

Belinda Parker Author The Sir Peter MacCallum Department of Oncology

Robin Anderson Author The Sir Peter MacCallum Department of Oncology

Related Projects (1)

A specific group of proteases contribute to the spread of breast cancer to bone

Breast cancer is a serious clinical problem once the disease spreads to distant tissues such as lung and bone. We have identified a group of..

Grants

Awarded by U.S. Department of Defense BCRP

Awarded by National Health and Medical Research Council (NHMRC)

Awarded by NIH

Awarded by NIH/National Cancer Institute

Awarded by NATIONAL CANCER INSTITUTE

Funding Acknowledgements

This work was supported by the U.S. Department of Defense BCRP Concept Award W81XWH-05-1-0444 (B. S. Parker), National Health and Medical Research Council (NHMRC) grant 509325 (B. S. Parker, R. L. Anderson, and M. S. Bogyo) and Career Development Award 566553 (B. S. Parker), National Breast Cancer Foundation (Australia) fellowship (R. L. Anderson), NHMRC postgraduate scholarship ID 466645 (to N.P. Withana). This work was also supported, in part, by the NIH [R01CA131990 (B. F. Sloane)] and NIH/National Cancer Institute grant ROI CA90291 (R. L. Anderson).