Journal article

Placental CLIC3 is increased in fetal growth restriction and pre-eclampsia affected human pregnancies

P Murthi, JL Stevenson, TT Money, AJ Borg, SP Brennecke, NM Gude

PLACENTA | W B SAUNDERS CO LTD | Published : 2012

Abstract

Chloride intracellular channel (CLIC) proteins constitute a subgroup of the glutathione-S-transferase (GSTs) superfamily. In humans, the CLIC family of proteins consists of six members, designated CLIC 1-6, which have a conserved C-terminal 240 residue module and one major transmembrane domain. CLIC proteins regulate fundamental cellular processes including regulation of chloride ion concentration, stabilization of cell membrane potential, trans-epithelial transport, regulation of cell volume and stimulation of apoptotic processes in response to cellular stress. Previously, we described the expression profile of a member of the CLIC family of proteins, CLIC3, in human placentae and fetal mem..

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