Journal article
Progressive gait deterioration in adolescents with Dravet syndrome
JM Rodda, IE Scheffer, JM McMahon, SF Berkovic, HK Graham
Archives of Neurology | Published : 2012
Abstract
Objective: To characterize changes in gait by age in patients with Dravet syndrome. Design: Prospective, cross-sectional study. Setting: Tertiary children's hospital. Patients: Twenty-six subjects with Dravet syndrome, aged 2 to 34 years. Twenty-three patients had mutations of the sodium channel α1 subunit gene, SCN1A. Interventions: Assessment via video gait analysis, physical examination of the lower limbs, use of the Functional Mobility Scale, and radiographs of the pelvis and feet. Main Outcome Measures: Classification of the sagittal gait pattern and foot posture, assessment of muscle extensibility and joint range, and rating of functional mobility. Results: Children aged 0 to 5 years h..
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Funding Acknowledgements
Dr Scheffer has served on scientific advisory boards for UCB and Janssen-Cilag EMEA; serves on the editorial boards of Annals of Neurology and Epileptic Disorders; may accrue future revenue on pending patent WO61/010176 (filed 2008; "Therapeutic Compound"); has received speaker honoraria from Athena Diagnostics, UCB, Biocodex, and Janssen-Cilag EMEA; has received funding for travel from Athena Diagnostics, UCB, Biocodex, and Janssen-Cilag EMEA; and receives or has received research support from the National Health and Medical Research Council of Australia, Health Research Council of New Zealand, University of Melbourne, American Epilepsy Society, Jack Brockhoff Foundation, Shepherd Foundation, and Perpetual Charitable Trustees. Dr Berkovic has served on scientific advisory boards for UCB and Janssen-Cilag EMEA; serves on the editorial boards of Lancet Neurology, Brain, and Epileptic Disorders; may accrue future revenue on pending patent WO61/010176 (filed 2008; "Therapeutic Compound"); has received unrestricted educational grants from UCB, Janssen-Cilag EMEA, and sanofi-aventis; and receives or has received research support from the National Health and Medical Research Council of Australia.