Journal article

Silencing of Irf7 pathways in breast cancer cells promotes bone metastasis through immune escape

Bradley N Bidwell, Clare Y Slaney, Nimali P Withana, Sam Forster, Yuan Cao, Sherene Loi, Daniel Andrews, Thomas Mikeska, Niamh E Mangan, Shamith A Samarajiwa, Nicole A de Weerd, Jodee Gould, Pedram Argani, Andreas Moeller, Mark J Smyth, Robin L Anderson, Paul J Hertzog, Belinda S Parker

Nature Medicine | NATURE PUBLISHING GROUP | Published : 2012

Grants

Awarded by Cancer Research UK


Awarded by National Breast Cancer Foundation


Funding Acknowledgements

This work was supported by the Cancer Council Victoria (B.S.P.), the Australian National Health and Medical Research Council (NHMRC) (P.J.H.), the Association of International Cancer Research (AICR) (A.M.), the Operational Infrastructure Scheme of the Victorian State government Department of Business and Innovation, the Australian Research Council (ARC) Centre for Structural and Functional Microbial Genomics and fellowship support for B.S.P. (NHMRC), R.L.A. (Australian National Breast Cancer Foundation, NBCF), A.M. (NBCF), C.Y.S. (NBCF, Cure Cancer Australia). We thank P. Hill (St Vincent's Pathology, St Vincent's Hospital, Fitzroy, Australia) for providing archived human breast cancer tissues assistance in the pathological assessment of immunohistochemistry staining and B. Haibe-Kains for assistance with codes in R. We also thank F. Miller (Karmanos Cancer Institute, Detroit, MI) for providing 66cl4 and 4T1 cell lines.