The enteric nervous system and neurogastroenterology
John B Furness
Nature Reviews Gastroenterology & Hepatology | NATURE PUBLISHING GROUP | Published : 2012
Neurogastroenterology is defined as neurology of the gastrointestinal tract, liver, gallbladder and pancreas and encompasses control of digestion through the enteric nervous system (ENS), the central nervous system (CNS) and integrative centers in sympathetic ganglia. This Review provides a broad overview of the field of neurogastroenterology, with a focus on the roles of the ENS in the control of the musculature of the gastrointestinal tract and transmucosal fluid movement. Digestion is controlled through the integration of multiple signals from the ENS and CNS; neural signals also pass between distinct gut regions to coordinate digestive activity. Moreover, neural and endocrine control of ..View full abstract
Work from the author's laboratory is supported by the National Health and Medical Research Council of Australia. I thank Dr Alan Lomax and Dr Daniel Poole for their helpful comments and Dr Trung Nguyen for assistance with the figures.