Journal article
Long-term seizure outcome and risk factors for recurrence after extratemporal epilepsy surgery
AM McIntosh, CA Averill, RM Kalnins, LA Mitchell, GCA Fabinyi, GD Jackson, SF Berkovic
Epilepsia | Published : 2012
Abstract
Purpose: We aimed to assess long-term seizure outcome and risk factors for seizure recurrence in a cohort of patients who have undergone extratemporal resection for management of refractory seizures. Methods: Eighty-one patients underwent extratemporal resection at Austin Health, Melbourne, Australia (1991-2004). Seizure recurrence was any postoperative disabling seizure (complex partial seizure [CPS] ± secondary generalization). Multivariate Cox proportional hazards regression models examined potential preoperative and perioperative risk factors and the risk associated with early postoperative seizures (≤28 days postsurgery). The change between preoperative and postoperative seizure frequen..
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Funding Acknowledgements
We dedicate this article to the memory of Dr. L. Anne Mitchell who passed away unexpectedly in September 2010. She was an invaluable contributor to clinical care and research at our Epilepsy Centre and is much missed. The authors thank the neurologists who provided information that assisted with follow-up. This research was supported in part by the Australian National Health and Medical Research Council Australia and Austin Hospital Medical Research Foundation (Austin Health, Australia). Dr. McIntosh was the recipient of an Early Career Researcher Grant from The University of Melbourne, Australia.