Journal article

Mammographic Breast Density and Breast Cancer: Evidence of a Shared Genetic Basis

Jajini S Varghese, Deborah J Thompson, Kyriaki Michailidou, Sara Lindstroem, Clare Turnbull, Judith Brown, Jean Leyland, Ruth ML Warren, Robert N Luben, Ruth J Loos, Nicholas J Wareham, Johanna Rommens, Andrew D Paterson, Lisa J Martin, Celine M Vachon, Christopher G Scott, Elizabeth J Atkinson, Fergus J Couch, Carmel Apicella, Melissa C Southey Show all

Cancer Research | AMER ASSOC CANCER RESEARCH | Published : 2012


Awarded by National Cancer Institute

Awarded by Wellcome Trust

Awarded by Era of Hope Award

Awarded by Medical Research Council

Awarded by Cancer Research UK

Awarded by National Breast Cancer Foundation

Awarded by The Francis Crick Institute


Funding Acknowledgements

MODE breast density GWAS: This study was supported by Public Health Service Grants CA131332, CA087969, CA049449 from the National Cancer Institute, NIH Department of Health and Human Services. The NHS breast cancer eases and controls were genotyped with support from the National Cancer Institute's Cancer Markers of Susceptibility (CGEMS) initiative. Data evaluation of mammograms and analysis of the EPIC-Norfolk study was supported by Cancer Research (UK). The SASBAC study was supported by Marit & Hans Rausing's Initiative against Breast Cancer, NIH, Susan Komen Foundation and Agency for Science, Technology and Research of Singapore (A*STAR). Genotyping in the Toronto/Melbourne subjects was supported by the Campbell Family Institute for Breast Cancer Research. Support was also provided by the Ontario Ministry of Health and Long Term Care.UK2 breast cancer GWAS: This work was supported by the Wellcome Trust and by Cancer Research UK. C. Turnbull is funded by a Medical Research Council Clinical Research Fellowship. The samples were collected and screened for BRCA mutations through funding from Cancer Research UK; US Military Acquisition (ACQ) Activity, Era of Hope Award (W81XWH-05-1-0204), and the Institute of Cancer Research (UK). This study makes use of data generated by the Wellcome Trust Case Control Consortium (WTCCC) 2. A full list of the investigators who contributed to the generation of the data is available from the WTCCC website. The British 1958 Birth Cohort collection was funded by the Medical Research Council grant G0000934 and the Wellcome Trust grant 068545/Z/02. Funding for this project was provided by the Wellcome Trust under award 085475.J.S. Varghese is funded by The Cambridge Commonwealth Trust and a Cambridge Overseas Research Scholarship. D.F. Easton is a Principal Research Fellow of Cancer Research (UK).