Journal article
Mammographic breast density and breast cancer: Evidence of a shared genetic basis
JS Varghese, DJ Thompson, K Michailidou, S Lindström, C Turnbull, J Brown, J Leyland, RML Warren, RN Luben, RJ Loos, NJ Wareham, J Rommens, AD Paterson, LJ Martin, CM Vachon, CG Scott, EJ Atkinson, FJ Couch, C Apicella, MC Southey Show all
Cancer Research | AMER ASSOC CANCER RESEARCH | Published : 2012
Abstract
Percent mammographic breast density (PMD) is a strong heritable risk factor for breast cancer. However, the pathways through which this risk is mediated are still unclear. To explore whether PMD and breast cancer have a shared genetic basis, we identified genetic variants most strongly associated with PMD in a published metaanalysis of five genome-wide association studies (GWAS) and used these to construct risk scores for 3,628 breast cancer cases and 5,190 controls from the UK2 GWAS of breast cancer. The signed per-allele effect estimates of single-nucleotide polymorphisms (SNP) were multiplied with the respective allele counts in the individual and summed over all SNPs to derive the risk s..
View full abstractGrants
Awarded by European Commission
Funding Acknowledgements
MODE breast density GWAS: This study was supported by Public Health Service Grants CA131332, CA087969, CA049449 from the National Cancer Institute, NIH Department of Health and Human Services. The NHS breast cancer eases and controls were genotyped with support from the National Cancer Institute's Cancer Markers of Susceptibility (CGEMS) initiative. Data evaluation of mammograms and analysis of the EPIC-Norfolk study was supported by Cancer Research (UK). The SASBAC study was supported by Marit & Hans Rausing's Initiative against Breast Cancer, NIH, Susan Komen Foundation and Agency for Science, Technology and Research of Singapore (A*STAR). Genotyping in the Toronto/Melbourne subjects was supported by the Campbell Family Institute for Breast Cancer Research. Support was also provided by the Ontario Ministry of Health and Long Term Care. UK2 breast cancer GWAS: This work was supported by the Wellcome Trust and by Cancer Research UK. C. Turnbull is funded by a Medical Research Council Clinical Research Fellowship. The samples were collected and screened for BRCA mutations through funding from Cancer Research UK; US Military Acquisition (ACQ) Activity, Era of Hope Award (W81XWH-05-1-0204), and the Institute of Cancer Research (UK). This study makes use of data generated by the Wellcome Trust Case Control Consortium (WTCCC) 2. A full list of the investigators who contributed to the generation of the data is available from the WTCCC website. The British 1958 Birth Cohort collection was funded by the Medical Research Council grant G0000934 and the Wellcome Trust grant 068545/Z/02. Funding for this project was provided by the Wellcome Trust under award 085475. J.S. Varghese is funded by The Cambridge Commonwealth Trust and a Cambridge Overseas Research Scholarship. D.F. Easton is a Principal Research Fellow of Cancer Research (UK).