Genome-wide association analysis identifies three new breast cancer susceptibility loci

M Ghoussaini; O Fletcher; K Michailidou; C Turnbull; MK Schmidt; E Dicks; J Dennis; Q Wang; MK Humphreys; C Luccarini; C Baynes; D Conroy; M Maranian; S Ahmed; K Driver; N Johnson; N Orr; I Dos Santos Silva; Q Waisfisz; H Meijers-Heijboer; AG Uitterlinden; F Rivadeneira; P Hall; K Czene; A Irwanto; J Liu; H Nevanlinna; K Aittom Currency Signki; C Blomqvist; A Meindl; RK Schmutzler; B Müller-Myhsok; P Lichtner; J Chang-Claude; R Hein; S Nickels; D Flesch-Janys; H Tsimiklis; E Makalic; D Schmidt; M Bui; JL Hopper; C Apicella; DJ Park; M Southey; DJ Hunter; SJ Chanock; A Broeks; S Verhoef; FBL Hogervorst; PA Fasching; MP Lux; MW Beckmann; AB Ekici; E Sawyer; I Tomlinson; M Kerin; F Marme; A Schneeweiss; C Sohn; B Burwinkel; P Guénel; T Truong; E Cordina-Duverger; F Menegaux; SE Bojesen; BG Nordestgaard; SF Nielsen; H Flyger; RL Milne; MR Alonso; A Gonzlez-Neira; J Ben-tez; H Anton-Culver; A Ziogas; L Bernstein; CC Dur; H Brenner; H Müller; V Arndt; C Stegmaier; C Justenhoven; H Brauch; T Brüning; WG Shan; U Eilber; T Dörk; P Schürmann; M Bremer; P Hillemanns; NV Bogdanova; NN Antonenkova; YI Rogov; JH Karstens; M Bermisheva; D Prokofieva; E Khusnutdinova; A Lindblom; S Margolin; A Mannermaa

Journal article

Genome-wide association analysis identifies three new breast cancer susceptibility loci

M Ghoussaini, O Fletcher, K Michailidou, C Turnbull, MK Schmidt, E Dicks, J Dennis, Q Wang, MK Humphreys, C Luccarini, C Baynes, D Conroy, M Maranian, S Ahmed, K Driver, N Johnson, N Orr, I Dos Santos Silva, Q Waisfisz, H Meijers-Heijboer Show all

Nature Genetics | NATURE PUBLISHING GROUP | Published : 2012

DOI: 10.1038/ng.1049

Abstract

Breast cancer is the most common cancer among women. To date, 22 common breast cancer susceptibility loci have been identified accounting for g1/48% of the heritability of the disease. We attempted to replicate 72 promising associations from two independent genome-wide association studies (GWAS) in g1/470,000 cases and ĝ̂1/468,000 controls from 41 case-control studies and 9 breast cancer GWAS. We identified three new breast cancer risk loci at 12p11 (rs10771399; P = 2.7 - 10 g35), 12q24 (rs1292011; P = 4.3 - 10 g19) and 21q21 (rs2823093; P = 1.1 - 10 g12). rs10771399 was associated with similar relative risks for both estrogen receptor (ER)-negative and ER-positive breast cancer, whereas the..

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