Journal article
Confinement of acoustic cavitation for the synthesis of protein-shelled nanobubbles for diagnostics and nucleic acid delivery
M Zhou, F Cavalieri, F Caruso, M Ashokkumar
ACS Macro Letters | AMER CHEMICAL SOC | Published : 2012
DOI: 10.1021/mz3002534
Abstract
We report a novel flow-through sonication technique for synthesizing stable and monodispersed nano-and micrometer-sized bubbles that have potential applications in diagnostics and gene therapy. The size and size distribution of the bubbles are controlled by the active cavitation zone generated by ultrasound. These bubbles are shown to possess echogenic properties and can be used for loading oligonucleotides. © 2012 American Chemical Society.
Grants
Funding Acknowledgements
The authors acknowledge the financial support from the Australian Research Council under the under the Federation Fellowship (F.C.) and Discovery Project (M.A.) schemes.