Serum Concentrations of Soluble Flt-1 Are Decreased among Women with a Viable Fetus and No Symptoms of Miscarriage Destined for Pregnancy Loss
Tu'uhevaha J Kaitu'u-Lino, Clare L Whitehead, Gene-Lyn Ngian, Michael Permezel, Stephen Tong
PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2012
Miscarriage is the most common complication of pregnancy. Pre-clinical miscarriage has an estimated incidence of 30%, whilst clinical miscarriage has an incidence of 12-15%. Two thirds of pregnancies lost to miscarriage are believed to be attributable to defective placentation, thus a number of studies have sought to identify markers of defective placentation that could be used as clinical biomarkers of miscarriage. Decreased soluble FMS-like tyrosine kinase-1 (sFlt1), placental growth factor (PlGF), and soluble endoglin (sEng) in the maternal circulation during the first trimester have recently been proposed as potential markers of pregnancy loss. However, in these studies clinical samples ..View full abstract
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Awarded by National Health and Medical Research Council of Australia
This study was supported by the Victorian Government's Operational Infrastructure Support Program. The National Health and Medical Research Council of Australia provided salary support (#490970 to S. T.; #490995 to T. K.). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.