Journal article

MMP-15 Is Upregulated in Preeclampsia, but Does Not Cleave Endoglin to Produce Soluble Endoglin

Tu'uhevaha J Kaitu'u-Lino, Kirsten Palmer, Laura Tuohey, Louie Ye, Stephen Tong

PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2012

Abstract

Preeclampsia is a major pregnancy complication, characterized by severe endothelial dysfunction, hypertension and maternal end-organ damage. Soluble endoglin is an anti-angiogenic protein released from placenta and thought to play a central role in causing the endothelial dysfunction and maternal organ injury seen in severe preeclampsia. We recently reported MMP-14 was the protease producing placentally-derived soluble endoglin by cleaving full-length endoglin present on the syncytiotrophoblast surface. This find identifies a specific drug target for severe preeclampsia; interfering with MMP-14 mediated cleavage of endoglin could decrease soluble endoglin production, ameliorating clinical di..

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Grants

Awarded by National Health and Medical Research Council of Australia


Funding Acknowledgements

This study was supported by the Victorian Government's Operational Infrastructure Support Program. The National Health and Medical Research Council of Australia provided salary support (#490970 to S.T.; #490995 to T.K.). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.