Hypoxanthine-xanthine oxidase down-regulates GLUT1 transcription via SIRT1 resulting in decreased glucose uptake in human placenta

Martha Lappas; Sofianos Andrikopoulos; Michael Permezel

Journal article

Hypoxanthine-xanthine oxidase down-regulates GLUT1 transcription via SIRT1 resulting in decreased glucose uptake in human placenta

Martha Lappas, Sofianos Andrikopoulos, Michael Permezel

JOURNAL OF ENDOCRINOLOGY | BIOSCIENTIFICA LTD | Published : 2012

DOI: 10.1530/JOE-11-0355

University of Melbourne Researchers

Michael Permezel Author Obstetrics and Gynaecology Royal Women's Hospital/Mercy

Sof Andrikopoulos Author Medicine - Austin Health

Related Projects (1)

Understanding the pathophysiology of Gestational Diabetes Mellitus

Gestational Diabetes Mellitus (GDM), which is defined as glucose intolerance of variable severity with onset or first recognition during pre..

Grants

Awarded by National Health and Medical Research Council (NHMRC)

Funding Acknowledgements

Dr M L was a recipient of a National Health and Medical Research Council (NHMRC) RD Wright Fellowship (grant no. 454777). The work described in this manuscript was, in part, funded by a project grant from NHMRC (grant no. 454310). Funding for the iQ5 multicolour RT-PCR machine (in-part), Chemi-Doc system and xMark Microplate Absorbance Spectrophotometer was provided by the Medical Research Foundation for Women and Babies.