Immobilization and intracellular delivery of an anticancer drug using mussel-inspired polydopamine capsules

J Cui; Y Yan; GK Such; K Liang; CJ Ochs; A Postma; F Caruso

Journal article

Immobilization and intracellular delivery of an anticancer drug using mussel-inspired polydopamine capsules

J Cui, Y Yan, GK Such, K Liang, CJ Ochs, A Postma, F Caruso

Biomacromolecules | Published : 2012

DOI: 10.1021/bm300835r

Abstract

We report a facile approach to immobilize pH-cleavable polymer-drug conjugates in mussel-inspired polydopamine (PDA) capsules for intracellular drug delivery. Our design takes advantage of the facile PDA coating to form capsules, the chemical reactivity of PDA films, and the acid-labile groups in polymer side chains for sustained pH-induced drug release. The anticancer drug doxorubicin (Dox) was conjugated to thiolated poly(methacrylic acid) (PMA SH) with a pH-cleavable hydrazone bond, and then immobilized in PDA capsules via robust thiol-catechol reactions between the polymer-drug conjugate and capsule walls. The loaded Dox showed limited release at physiological pH but significant release ..

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University of Melbourne Researchers

Georgina Such Author

Frank Caruso Author

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Grants

Awarded by Australian Research Council

Funding Acknowledgements

This work was supported by the Australian Research Council under the Federation Fellowship and Discovery Project schemes (F.C.). J.C. is the recipient of an Australian Research Council Super Science Fellowship (FS110200025). J.C. acknowledges the support of an Early Career Research Grant from The University of Melbourne.