Journal article
Mu opioid receptor availability in people with psychiatric disorders who died by suicide: a case control study
E Scarr, TT Money, G Pavey, J Neo, B Dean
BMC Psychiatry | BMC | Published : 2012
Abstract
Background: Mu opioid receptors have previously been shown to be altered in people with affective disorders who died as a result of suicide. We wished to determine whether these changes were more widespread and independent of psychiatric diagnoses.Methods: Mu receptor levels were determined using [3 H]DAMGO binding in BA24 from 51 control subjects; 38 people with schizophrenia (12 suicides); 20 people with major depressive disorder (15 suicides); 13 people with bipolar disorder (5 suicides) and 9 people who had no history of psychiatric disorders but who died as a result of suicide. Mu receptor levels were further determined in BA9 and caudate-putamen from 38 people with schizophrenia and 20..
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Grants
Awarded by MedStar Health Research Institute
Funding Acknowledgements
This study was supported by an NHMRC project grant (#509306) and Operational Infrastructure Support (OIS) from the Victorian State Government. Partial funding for the Kodak Image Station 440CF was provided by Equity Trustees. ES was the Royce Abbey Postdoctoral Fellow and TM was an Ian Scott scholar, both funded by the Australian Rotary Health Research Fund. ES is now an ARC Future Fellow (FT100100689). BD is a NH&MRC Senior Research Fellow (#APP1002240). The Victorian Brain Bank Network is supported by the Mental Health Research Institute, The Alfred, Victorian Forensic Institute of Medicine, The University of Melbourne and funded by Australia's National Health & Medical Research Council, Helen Macpherson Smith Trust, Parkinson's Victoria and Perpetual Philanthropic Services.