Journal article
Mechanisms of red blood cells agglutination in antibody-treated paper
P Jarujamrus, J Tian, X Li, A Siripinyanond, J Shiowatana, W Shen
Analyst | Published : 2012
DOI: 10.1039/c2an15798e
Abstract
Recent reports on using bio-active paper and bio-active thread to determine human blood type have shown a tremendous potential of using these low-cost materials to build bio-sensors for blood diagnosis. In this work we focus on understanding the mechanisms of red blood cell agglutination in the antibody-loaded paper. We semi-quantitatively evaluate the percentage of antibody molecules that are adsorbed on cellulose fibres and can potentially immobilize red blood cells on the fibre surface, and the percentage of the molecules that can desorb from the cellulose fibre surface into the blood sample and cause haemagglutination reaction in the bulk of a blood sample. Our results show that 34 to 42..
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Awarded by Australian Research Council (ARC)
Funding Acknowledgements
This work is supported by the Australian Research Council Grant (ARC DP1094179). Purim Jarujamrus is grateful for the research grants from the Thailand Research Fund (TRF) through the Royal Golden Jubilee PhD Program (RGJ) and Center of Excellence for Innovation in Chemistry (PERCH-CIC), Commission on Higher Education, Ministry of Education. The authors also would like to thank the kind blood donors who have made this work possible. Thanks are also given to Ms Lisa Collision of the Monash University Health Service for her help in collecting the blood samples.