Journal article
High-density epicardial mapping of the pulmonary vein-left atrial junction in humans: Insights into mechanisms of pulmonary vein arrhythmogenesis
G Lee, S Spence, A Teh, J Goldblatt, M Larobina, V Atkinson, R Brown, JB Morton, P Sanders, PM Kistler, JM Kalman
Heart Rhythm | ELSEVIER SCIENCE INC | Published : 2012
Abstract
Background: The pulmonary veins (PVs) and the PVLA (left atrium) junction are established sources of triggers initiating atrial fibrillation. In addition, they have been implicated in the maintenance of arrhythmia. Objective: To undertake high-density electrophysiological characterization of the right superior PVLA junction in humans. Methods: Mapping was performed in 18 patients without a history of atrial fibrillation undergoing cardiac surgery. A high-density epicardial plaque was positioned at the anterior right superior pulmonary vein covering 3 regions: LA, PVLA junction, and the PV. Isochronal maps were created during (1) sinus rhythm (SR); (2) LA pacing (LA-Pace); (3) PV pacing (PV-P..
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Funding Acknowledgements
Dr Lee is the recipient of a postgraduate research scholarship from the National Health and Medical Research Council of Australia and a postgraduate research scholarship from the Cardiac Society of Australia and New Zealand. Dr Teh is the recipient of a postgraduate research scholarship from the National Heart Foundation of Australia. Dr Lee and Dr Teh are recipients of a cardiovascular and lipid research grant from Pfizer. Dr Kistler is supported by a research investigatorship from the Cardiac Society of Australia and New Zealand. Dr Sanders reports having served on the advisory board of Bard Electrophysiology, Biosense-Webster, Medtronic, St Jude Medical, Sanofi-Aventis, Merck, Sharpe, and Dohme. Dr Sanders reports having received lecture fees and research funding from Bard Electrophysiology, Biosense-Webster, Medtronic, and St Jude Medical.