The tumor suppressor Apc controls planar cell polarities central to gut homeostasis
Julien Bellis, Isabelle Duluc, Beatrice Romagnolo, Christine Perret, Maree C Faux, Denis Dujardin, Caroline Formstone, Sally Lightowler, Robert G Ramsay, Jean-Noel Freund, Jan R De Mey
JOURNAL OF CELL BIOLOGY | ROCKEFELLER UNIV PRESS | Published : 2012
The stem cells (SCs) at the bottom of intestinal crypts tightly contact niche-supporting cells and fuel the extraordinary tissue renewal of intestinal epithelia. Their fate is regulated stochastically by populational asymmetry, yet whether asymmetrical fate as a mode of SC division is relevant and whether the SC niche contains committed progenitors of the specialized cell types are under debate. We demonstrate spindle alignments and planar cell polarities, which form a novel functional unit that, in SCs, can yield daughter cell anisotropic movement away from niche-supporting cells. We propose that this contributes to SC homeostasis. Importantly, we demonstrate that some SC divisions are asym..View full abstract
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Support was given to J. Bellis by the Ligue Contre le Cancer and to R.G. Ramsay and M.C. Faux by the National Health and Medical Research Council, Australia.