Human relaxin-2: Historical perspectives and role in cancer biology

VB Nair; CS Samuel; F Separovic; MA Hossain; JD Wade

Journal article

Human relaxin-2: Historical perspectives and role in cancer biology

VB Nair, CS Samuel, F Separovic, MA Hossain, JD Wade

Amino Acids | SPRINGER WIEN | Published : 2012

DOI: 10.1007/s00726-012-1375-y

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Abstract

One of the most recognised and studied family of peptide hormones is the insulin superfamily. Within this family is the relaxin subfamily which comprises seven members: relaxin-1, -2 and -3 and insulin-like peptides 3, 4, 5 and 6. Besides exhibiting sequence similarities, each member exists as an active A-B heterodimer linked by three disulfide bonds. This mini-review is divided into three broad themes: an overview of all insulin superfamily members (including structural similarities); roles of each superfamily member and finally, a focus on the pleiotropic peptide hormone, human relaxin-2. In addition to promoting vasodilatory effects leading to evaluation in Phase III clinical trials for t..

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University of Melbourne Researchers

Frances Separovic Author

Akhter Hossain Author

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Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

V.B.N. is a recipient of a Melbourne Research Scholarship by the University of Melbourne; C. S. S. is supported by a National Heart Foundation of Australia and National Health and Medical Research Council (NHMRC) of Australia RD Wright Fellowship; M. A. H was the recipient of Reid Trust and Florey Foundation Trust Fellowships and J.D.W is an NHMRC Principal Research Fellow. Some of the authors' research reported in this review was supported by NHMRC Project Grants 508995 and 1023078. Research at the FNI was supported by the Victorian Government's Operational Infrastructure Support Program.