Journal article

Feasibility, Safety, and Compliance in a Randomized Controlled Trial of Physical Therapy for Parkinson's Disease

Jennifer L McGinley, Clarissa Martin, Frances E Huxham, Hylton B Menz, Mary Danoudis, Anna T Murphy, Jennifer J Watts, Robert Iansek, Meg E Morris



Both efficacy and clinical feasibility deserve consideration in translation of research outcomes. This study evaluated the feasibility of rehabilitation programs within the context of a large randomized controlled trial of physical therapy. Ambulant participants with Parkinson's disease (PD) (n = 210) were randomized into three groups: (1) progressive strength training (PST); (2) movement strategy training (MST); or (3) control ("life skills"). PST and MST included fall prevention education. Feasibility was evaluated in terms of safety, retention, adherence, and compliance measures. Time to first fall during the intervention phase did not differ across groups, and adverse effects were minima..

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Awarded by National Health and Medical Research Council (Clinical Career Development Award)

Funding Acknowledgements

This project has been funded by a Michael J Fox Foundation (US) Clinical Discovery Grant. H. B. Menz is currently a National Health and Medical Research Council Fellow (Clinical Career Development Award, ID: 433049).