Journal article

Evidence for genetic factors in vasovagal syncope A twin-family study

Karl Martin Klein, San San Xu, Kate Lawrence, Alexandra Fischer, Samuel F Berkovic

NEUROLOGY | LIPPINCOTT WILLIAMS & WILKINS | Published : 2012

Abstract

OBJECTIVE: Vasovagal syncope (VVS) is the most frequent type of syncope and a common differential diagnosis of epilepsy. The role of genetic factors in VVS is debated. We performed a twin-family study to clarify this question and to analyze the putative mode of inheritance. METHODS: Fifty-one same-sex twin pairs where at least 1 had syncope were ascertained. The twins were interviewed via telephone using a standardized questionnaire. Available medical records were obtained. Information on the affected status of first- and second-degree relatives was acquired. RESULTS: There was a trend toward higher casewise concordance in monozygous (MZ, 0.75) than dizygous (DZ, 0.50) twins for any syncope ..

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Grants

Awarded by National Health and Medical Research Council of Australia


Awarded by Deutsche Forschungsgemeinschaft


Funding Acknowledgements

Supported by a project grant (ID 509135) and an enabling grant (ID 628911) of the National Health and Medical Research Council of Australia. K.M.K. was supported by a research fellowship from the Deutsche Forschungsgemeinschaft (KL 2254/1-1) and a scholarship from The University of Melbourne.K. Klein was funded by a research fellowship from the Deutsche Forschungsgemeinschaft (KL 2254/1-1) and a scholarship from The University of Melbourne. S. Xu, K. Lawrence, and A. Fischer report no disclosures. S. Berkovic has served on scientific advisory boards for UCB and Janssen-Cilag; may accrue future revenue on pending patent WO61/010176 (filed: 2008): Therapeutic Compound; has received speaker honoraria from UCB; has received unrestricted educational grants from UCB, Janssen-Cilag, and Sanofi-Aventis; and receives/has received research support from the National Health and Medical Research Council of Australia and The University of Melbourne. Go to Neurology.org for full disclosures.