Journal article

Less fat reduction per unit weight loss in type 2 diabetic compared with nondiabetic obese individuals completing a very-low-calorie diet program

Scott T Baker, George Jerums, Luke A Prendergast, Sianna Panagiotopoulos, Boyd J Strauss, Joseph Proietto

METABOLISM-CLINICAL AND EXPERIMENTAL | W B SAUNDERS CO-ELSEVIER INC | Published : 2012

Abstract

The objective was to compare weight loss and change in body composition in obese subjects with and without type 2 diabetes mellitus during a very-low-calorie diet (VLCD) program. Seventy weight-matched subjects with diabetes or normal fasting glucose (controls) participated in a 24-week VLCD study. Primary end points were changes in anthropometry, body composition, and fasting plasma insulin and β-hydroxybutyrate concentrations. Fifty-one subjects (24 with diabetes) completed the study. No difference in weight loss between the 2 groups at 24 weeks was found by intention-to-treat analysis. Both groups completing the study per protocol had near-identical weight change during the program, with ..

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Grants

Funding Acknowledgements

JP is supported by the Sir Edward Dunlop Medical Research Foundation. During the study period, STB received a training scholarship from the National Health and Medical Research Council. This study was supported by a Pfizer CVL grant (2007) and a supporting grant from the Austin Hospital Medical Research Foundation (2010).During the study period, JP was Chair of the Optifast Medical Advisory Committee for Nestle Nutrition. STB has received a training scholarship from the National Health and Medical Research Council of Australia. JP is supported by the Sir Edward Dunlop Medical Research Foundation. No other conflicts of interest are identified.