Journal article
Conjugation of transferrin to azide-modified cdse/zns core-shell quantum dots using cyclooctyne click chemistry
C Schieber, A Bestetti, JP Lim, AD Ryan, TL Nguyen, R Eldridge, AR White, PA Gleeson, PS Donnelly, SJ Williams, P Mulvaney
Angewandte Chemie International Edition | Published : 2012
Abstract
Twinkle twinkle quantum dot: Conjugation of biomolecules to azide-modified quantum dots (QDs) through a bifunctional linker, using strain-promoted azide-alkyne cycloaddition with the QD and a squaramide linkage to the biomolecule (see scheme). Transferrin-conjugated QDs were internalized by transferrin-receptor expressing HeLa cells.
Grants
Funding Acknowledgements
This work was supported by the Faculty of Science, University of Melbourne, and the Australian Research Council (ARC).