Journal article
Cancer risks for the relatives of colorectal cancer cases with a methylated MLH1 promoter region: Data from the colorectal cancer family registry
AJ Levine, AK Win, DD Buchanan, MA Jenkins, JA Baron, JP Young, TI Long, DJ Weisenberger, PW Laird, RL McCall, DJ Duggan, RW Haile
Cancer Prevention Research | AMER ASSOC CANCER RESEARCH | Published : 2012
Abstract
Methylation of the MLH1 gene promoter region is an underlying cause of colorectal cancer (CRC) with high microsatellite instability (MSI-H) diagnosed in persons without a germ line mutation in a mismatch repair (MMR) gene (non-Lynch Syndrome CRC). It is unclear whether relatives of CRC cases with MLH1 methylation have an increased risk of colorectal or other cancers. In this retrospective cohort study, we assessed risk of CRC and other cancers for the first- and second-degree relatives of CRC cases with a methylated MLH1 gene, by comparing observed numbers of cases with those expected on the basis of age-, sex-, and country-specific cancer incidences (standardized incidence ratios). The coho..
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Awarded by National Cancer Institute
Funding Acknowledgements
This work was supported by the National Cancer Institute, NIH under RFA #CA-95-011 and through cooperative agreements with the Australasian Colorectal Cancer Family Registry (U01 CA097735), the USC Familial Colorectal Neoplasia Collaborative Group (U01 CA074799), the Ontario Registry for Studies of Familial Colorectal Cancer (U01 CA074783), the Seattle Colorectal Cancer Family Registry (U01 CA074794), and the University of Hawaii Colorectal Cancer Family Registry (U01 CA074806) as well as NCI R01 CA112237 (R.W. Haile). A.K. Win was supported by a grant from the Cancer Council Victoria and the Picchi Brothers Foundation, Australia.