Journal article
A DNA resequencing array for genes involved in Parkinson's disease
EJ Wilkins, JP Rubio, KE Kotschet, TF Cowie, WC Boon, M O'Hely, R Burfoot, W Wang, CM Sue, TP Speed, J Stankovitch, MK Horne
Parkinsonism and Related Disorders | ELSEVIER SCI LTD | Published : 2012
Abstract
Parkinson's disease (PD) is aetiologically complex with both familial and sporadic forms. Familial PD results from rare, highly penetrant pathogenic mutations whereas multiple variants of low penetrance may contribute to the risk of sporadic PD. Common variants implicated in PD risk appear to explain only a minor proportion of the familial clustering observed in sporadic PD. It is therefore plausible that combinations of rare and/or common variants in genes already implicated in disease pathogenesis may help to explain the genetic basis of PD. We have developed a CustomSeq Affymetrix resequencing array to enable high-throughput sequencing of 13 genes (44 kb) implicated in the pathogenesis of..
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Awarded by National Cancer Institute
Funding Acknowledgements
We thank Laura Johnson for sample handling and for funding of this research we are grateful to The Australian Research Council (Linkage Project: LPO776735), The Australian Brain Foundation and the Rebecca L. Cooper Medical Research Foundation.