Journal article
Adolescent Toluene Inhalation in Rats Affects White Matter Maturation with the Potential for Recovery Following Abstinence
JR Duncan, ALW Dick, G Egan, S Kolbe, M Gavrilescu, D Wright, DI Lubman, AJ Lawrence
Plos One | PUBLIC LIBRARY SCIENCE | Published : 2012
Open access
Abstract
Inhalant misuse is common during adolescence, with ongoing chronic misuse associated with neurobiological and cognitive abnormalities. While human imaging studies consistently report white matter abnormalities among long-term inhalant users, longitudinal studies have been lacking with limited data available regarding the progressive nature of such abnormalities, including the potential for recovery following periods of sustained abstinence. We exposed adolescent male Wistar rats (postnatal day 27) to chronic intermittent inhaled toluene (3,000 ppm) for 1 hour/day, 3 times/week for 8 weeks to model abuse patterns observed in adolescent and young adult human users. This dosing regimen resulted..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
This research was supported by The National Health and Medical Research Council of Australia of which AJL is a Principal Fellow (1020737), the Australian Research Council (DP 110100379) of which JRD is a Future Fellow (100100235), The Lew Carty Foundation and the Alcohol and Health Research Grant Scheme. The authors also acknowledge the Victorian Government's Operational Infrastructure Support Scheme. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.