Journal article

Over-expression of RCAN1 causes Down syndrome-like hippocampal deficits that alter learning and memory

Katherine R Martin, Alicia Corlett, Daphne Dubach, Tomris Mustafa, Harold A Coleman, Helena C Parkington, Tobias D Merson, James A Bourne, Silvia Porta, Maria L Arbones, David I Finkelstein, Melanie A Pritchard

HUMAN MOLECULAR GENETICS | OXFORD UNIV PRESS | Published : 2012

Abstract

People with Down syndrome (DS) exhibit abnormal brain structure. Alterations affecting neurotransmission and signalling pathways that govern brain function are also evident. A large number of genes are simultaneously expressed at abnormal levels in DS; therefore, it is a challenge to determine which gene(s) contribute to specific abnormalities, and then identify the key molecular pathways involved. We generated RCAN1-TG mice to study the consequences of RCAN1 over-expression and investigate the contribution of RCAN1 to the brain phenotype of DS. RCAN1-TG mice exhibit structural brain abnormalities in those areas affected in DS. The volume and number of neurons within the hippocampus is reduc..

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