Journal article

Neural correlates coding stimulus level and perception of capsaicin-evoked urge-to-cough in humans

Michael J Farrell, Leonie J Cole, David Chiapoco, Gary F Egan, Stuart B Mazzone



The perception of airways irritation is represented in a distributed brain network. However, the functional roles of sub-regions of this network are yet to be determined. The aim of this study was to measure brain activation in healthy participants as they inhaled two doses of capsaicin to identify dose-dependent and dose-independent responses. Blood oxygen level-dependent functional magnetic resonance imaging (fMRI) measures of brain responses during inhalation of saline, and a low and high dose of capsaicin were made from 16 healthy participants. Subjective ratings of the urge-to-cough were also made during capsaicin challenges. The majority of brain regions that were activated during caps..

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Awarded by NHMRC of Australia

Awarded by NHMRC

Funding Acknowledgements

These studies were funded by the NHMRC of Australia (566734). This funding source had no direct role in study design, data collection, analysis or the writing of this manuscript. SBM and GFE hold current NHMRC Fellowship grants (454776, 1025589 and 400317). At the time of this study KIF was a University of Melbourne C.R. Roper Fellow. The authors wish to express their appreciation to Mr Michael Kean of the Children's MRI Centre, Murdoch Children's Research Institute (Melbourne, Australia) for his assistance during the execution of this study.