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Journal article

The Tumor Suppressor PTEN Is Exported in Exosomes and Has Phosphatase Activity in Recipient Cells

Ulrich Putz, Jason Howitt, Anh Doan, Choo-Peng Goh, Ley-Hian Low, John Silke, Seong-Seng Tan

Science Signaling | AMER ASSOC ADVANCEMENT SCIENCE | Published : 2012

DOI: 10.1126/scisignal.2003084

University of Melbourne Researchers

Seong Tan's Profile Picture
Seong Tan Author Anatomy and Neuroscience

Jason Howitt's Profile Picture
Jason Howitt Author Florey Department of Neuroscience and Mental Health

John Silke's Profile Picture
John Silke Author Medical Biology (W.E.H.I.)

Grants

Funding Acknowledgements

This work was supported by the Australia National Health and Medical Research Council through a Program Grant and the Victorian Government through the Operational Infrastructure Scheme.

Citation metrics

190Web of Science
191Scopus
210Dimensions

Keywords

Exosomes
Hek293 Cells
Cell Biology
Mice
Vesicle
Ubiquitin Ligase
Identification
Mice, Knockout
Gene
Intercellular Signaling Peptides and Proteins
Science & Technology
Life Sciences & Biomedicine
Glioma-Cells
Nuclear Pten
Cell Proliferation
Tetrazolium Salts
Pten Phosphohydrolase
Blotting, Western
Electrophoresis, Polyacrylamide Gel
Biochemistry & Molecular Biology
Thiazoles
Ndfip1
Immunoprecipitation
Trypan Blue
Domain
Ubiquitin-Protein Ligases
Animals
Humans
Microscopy, Electron
Phosphorylation
Immunohistochemistry
Membrane Proteins
Oncogene Protein V-Akt
Endosomal Sorting Complexes Required for Transport
Nedd4 Ubiquitin Protein Ligases
Carrier Proteins
Expression
Proteins

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