Increased feeding and body weight gain in rats after acute and chronic activation of RXFP3 by relaxin-3 and receptor-selective peptides: functional and therapeutic implications
Despina E Ganella, Philip J Ryan, Ross AD Bathgate, Andrew L Gundlach
BEHAVIOURAL PHARMACOLOGY | LIPPINCOTT WILLIAMS & WILKINS | Published : 2012
This paper provides a review of the effects of relaxin-3 and structurally related analogues on food intake and related behaviours, in relation to hypothalamic neural networks and chemical messengers known to control feeding, metabolism and body weight, including other neuropeptides and hormones. Soon after relaxin-3 was discovered, pharmacological studies identified the ability of the native peptide to stimulate feeding acutely in adult rats. Although interpretation of these data was confounded by ligand cross-reactivity at relaxin-family peptide (RXFP) receptors, studies with relaxin-3 analogues selective for the native relaxin-3 receptor, RXFP3, confirmed that acute and chronic activation ..View full abstract
The authors thank Dr Fazel Shabanpoor (FNI) for providing the images of the relaxin-3 peptides, and Dr Pascal Bonaventure and Steve Sutton (Johnson & Johnson PR&D LLC, USA) for providing the RXFP3 mRNA autoradiograms. Research in the authors' laboratory is supported by grants from the National Health and Medical Research Council (NHMRC) of Australia (R.A.D.B., A.L.G.), the Besen Family and Pratt Foundations (A.L.G.) and by the Victorian Government Operational Infrastructure Support Program. D.E.G. and P.J.R. are recipients of Commonwealth Australian Postgraduate Awards and P.J.R. is the recipient of a Dowd Foundation Neuroscience Scholarship. R.A.D.B. and A.L.G. are recipients of NHMRC (Australia) Research Fellowships.