Journal article

Structures of the HIN Domain: DNA Complexes Reveal Ligand Binding and Activation Mechanisms of the AIM2 Inflammasome and IFI16 Receptor

Tengchuan Jin, Andrew Perry, Jiansheng Jiang, Patrick Smith, James A Curry, Leonie Unterholzner, Zhaozhao Jiang, Gabor Horvath, Vijay A Rathinam, Ricky W Johnstone, Veit Hornung, Eicke Latz, Andrew G Bowie, Katherine A Fitzgerald, T Sam Xiao

Immunity | CELL PRESS | Published : 2012

Grants

Awarded by Science Foundation Ireland


Awarded by NIH


Awarded by European Research Council


Awarded by DFG


Funding Acknowledgements

We thank the beam line scientists at the Argonne National Laboratory GM/CA-CAT (Argonne, IL) and the Brookhaven National Laboratory (Upton, NY) for their support on data collection. The authors would like to thank A. Mian from LI, NIAID for technical support. We thank R. Schwartz, M. Lenardo, and D. Margulies for helpful discussions. We thank D.E. Anderson at the Mass Spectrometry facility of NIDDK for technical support. T.S.X. is supported by the Division of Intramural Research, National Institute of Allergy and Infectious Diseases, NIH. A.G.B. and L.U. are supported by Science Foundation Ireland (07/IN1/B934). K.A.F. is supported by NIH grants AI083713 and AI067497. E.L. is supported by NIH grant AI067497. V.H. is supported by the European Research Council (ERC-2009-StG 243046) and the DFG (SFB704 and SFB670). R.W.J. is a Principal Research Fellow of the National Health and Medical Research Council of Australia (NHMRC) and supported by NHMRC Program and Project Grants, the Susan G. Komen Breast Cancer Foundation, the Prostate Cancer Foundation of Australia, Cancer Council Victoria, The Leukemia Foundation of Australia, Victorian Breast Cancer Research Consortium, and Victorian Cancer Agency. V.A.R. is supported by a NERCE Postdoctoral fellowship.