Journal article
Atrial electrical and structural remodeling associated with longstanding pulmonary hypertension and right ventricular hypertrophy in humans
C Medi, JM Kalman, LH Ling, AW Teh, G Lee, G Lee, SJ Spence, DM Kaye, PM Kistler
Journal of Cardiovascular Electrophysiology | WILEY | Published : 2012
Abstract
Introduction: Pulmonary hypertension (PH) is common to a range of cardiopulmonary conditions and is associated with atrial arrhythmias. However, little is known of the isolated atrial effects of PH and right atrial dilatation (RA) in humans. To avoid the confounding effects of PH-associated disease states, we performed detailed electrophysiological (EP) and electroanatomic (EA) mapping of the RA in patients with idiopathic PH. Methods and Results: Eight PH patients (mean pulmonary arterial [PA] pressure 39.0 ± 15.8 mmHg) and 16 age-matched controls (mean PA pressure 11.5 ± 4.1 mmHg, P < 0.0001) were studied. Corrected sinus node recovery times (cSNRT), atrial effective refractory periods (ER..
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Funding Acknowledgements
This study was supported by a grant in aid from the National Heart Foundation. Dr. Medi is supported by a medical postgraduate scholarship from the National Heart Foundation of Australia (NHFA), and was a recipient of a cardiovascular and lipid research grant from Pfizer. Dr. Ling is supported by a medical postgraduate scholarship from the National Health and Medical Research Council (NHMRC) of Australia. Dr. Teh is supported by a medical postgraduate scholarship from the National Health and Medical Research Council (NHMRC) of Australia and was a recipient of a cardiovascular and lipid research grant from Pfizer. Dr. Lee is supported by a medical postgraduate scholarship from the National Health and Medical Research Council (NHMRC) of Australia and was a recipient of a cardiovascular and lipid research grant from Pfizer. Prof. Kistler is supported by Research Investigatorship from the Cardiac Society of Australia and New Zealand. Other authors: No disclosures.Supported in part by the Victorian Government's Operational Infrastructure Support Program.