Maternal vitamin D predominates over genetic factors in determining neonatal circulating vitamin D concentrations

B Novakovic; JC Galati; A Chen; R Morley; JM Craig; R Saffery

Journal article

Maternal vitamin D predominates over genetic factors in determining neonatal circulating vitamin D concentrations

B Novakovic, JC Galati, A Chen, R Morley, JM Craig, R Saffery

American Journal of Clinical Nutrition | Published : 2012

DOI: 10.3945/ajcn.112.035683

Abstract

Background: There are multiple potential regulators of neonatal vitamin D status of environmental, genetic, and epigenetic origins. The relation between these factors and circulating neonatal vitamin D has yet to be fully characterized. Objective: The aim of this study was to examine the relative contribution of genetic factors, maternal circulating 25-hydroxyvitamin D [25(OH)D] concentrations, and the placental methylation level of the gene that encodes the primary catabolic enzyme of active vitamin D [25(OH)D-24-hydroxylase encoded by CYP24A1] to neonatal 25(OH)D concentrations. Design: We used the classical twin study design to determine the genetic contribution to neonatal 25(OH)D. A tot..

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University of Melbourne Researchers

Jeff Craig Author

Richard Saffery Author

Boris Novakovic Author

Grants

Awarded by Australian National Health and Medical Research Council (NHMRC)

Funding Acknowledgements

Supported by grants from the Australian National Health and Medical Research Council (NHMRC) (grants 437015 and 607358; to JMC and RS) and an Australian NHMRC Dora Lush Biomedical Research Scholarship (to BN). The Murdoch Childrens Research Institute is supported by the Victorian Government's Operational Infrastructure Support Program.