Journal article

Promoting engraftment of transplanted neural stem cells/progenitors using biofunctionalised electrospun scaffolds

Ting-Yi Wang, John S Forsythe, David R Nisbet, Clare L Parish

BIOMATERIALS | ELSEVIER SCI LTD | Published : 2012

Abstract

With the brain's limited capacity for repair, new and innovative approaches are required to promote regeneration. While neural transplantation for a number of neural disease/injuries have been demonstrated, major limitations in the field include poor cell survival and integration. This, in part, is due to the non-conducive environment of the adult brain, failing to provide adequate chemical and physical support for new neurons. Here we examine the capacity of fibrous poly ε-caprolactone (PCL) scaffolds, biofunctionalised with immobilised glial cell-derived neurotrophic factor (GDNF), to influence primary cortical neural stem cells/progenitors in vitro and enhance integration of these cells f..

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Grants

Funding Acknowledgements

We wish to thank Alexandra Rodriguez for critical reading of the manuscript. This research was supported by funding from the Bethlehem Griffith Research Foundation, Australia. D.R.N was supported by an Australian Research Council Australian Post-doctoral Fellowship. C.L.P was supported by an NHMRC Career Development Award, and subsequently Senior Medical Research Fellowship provided by the Viertel charitable Foundation, Australia.