Biofunctionalisation of polymeric scaffolds for neural tissue engineering
TY Wang, JS Forsythe, CL Parish, DR Nisbet
JOURNAL OF BIOMATERIALS APPLICATIONS | SAGE PUBLICATIONS LTD | Published : 2012
Patients who experience injury to the central or peripheral nervous systems invariably suffer from a range of dysfunctions due to the limited ability for repair and reconstruction of damaged neural tissue. Whilst some treatment strategies can provide symptomatic improvement of motor and cognitive function, they fail to repair the injured circuits and rarely offer long-term disease modification. To this end, the biological molecules, used in combination with neural tissue engineering scaffolds, may provide feasible means to repair damaged neural pathways. This review will focus on three promising classes of neural tissue engineering scaffolds, namely hydrogels, electrospun nanofibres and self..View full abstract
Awarded by ARC
DN is grateful to the Australian Research Council (A. R. C.) for an Australian Postdoctoral Fellowship.We also acknowledge the ARC Discovery Project Grant DP0985433 for funding. We also acknowledge the Bethlehem Griffith Research Foundation grant awarded to DN and CP.