Direct visualization and characterization of erythrocyte flow in human retinal capillaries
Phillip Bedggood, Andrew Metha
BIOMEDICAL OPTICS EXPRESS | OPTICAL SOC AMER | Published : 2012
Imaging the retinal vasculature offers a surrogate view of systemic vascular health, allowing noninvasive and longitudinal assessment of vascular pathology. The earliest anomalies in vascular disease arise in the microvasculature, however current imaging methods lack the spatiotemporal resolution to track blood flow at the capillary level. We report here on novel imaging technology that allows direct, noninvasive optical imaging of erythrocyte flow in human retinal capillaries. This was made possible using adaptive optics for high spatial resolution (1.5 μm), sCMOS camera technology for high temporal resolution (460 fps), and tunable wavebands from a broadband laser for maximal erythrocyte c..View full abstract
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Awarded by Australian Research Council
This project was supported by an Australian Research Council Discovery Early Career Researcher Award (DE120101931), an Australia Research Council Discovery Project Grant (DP0984649), an A.E. Rowden White Foundation benevolent bequest, and the University of Melbourne Interdisciplinary Seed Fund.