Differential Remodeling of Actin Cytoskeleton Architecture by Profilin Isoforms Leads to Distinct Effects on Cell Migration and Invasion
Ghassan Mouneimne, Scott D Hansen, Laura M Selfors, Lara Petrak, Michele M Hickey, Lisa L Gallegos, Kaylene J Simpson, James Lim, Frank B Gertler, John H Hartwig, R Dyche Mullins, Joan S Brugge
Cancer Cell | CELL PRESS | Published : 2012
Awarded by NIH
Awarded by NATIONAL CANCER INSTITUTE
Awarded by NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
Awarded by NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
We thank James Bui and Wa Xian for technical assistance; Rachel Davidowitz, Taru Muranen, and Scott Valastyan for their blinded analysis of the human tumor tissue arrays; the Nikon Imaging Center, particularly Jennifer Waters and Wendy Salmon; and the Rodent Histopathology Core Facility, particularly Roderick Bronson. This work was funded by the Breast Cancer Research Foundation, the NIGMS Cell Migration Consortium, a gift from the Lee Jeans Foundation through the Entertainment Industry Foundation (to J.S.B.); NIH Grant P01 HL059561 (to J.H.H.); NIH Grant ROI #GM61010, UCSF/UC Berkeley Nanomedicine Development Center and the National Science Foundation (to R.D.M. and S.D.H.); and NIH #GM58801 (to F.B.G.).