Proteomic and Metabolomic Analyses of Mitochondrial Complex I-deficient Mouse Model Generated by Spontaneous B2 Short Interspersed Nuclear Element (SINE) Insertion into NADH Dehydrogenase (Ubiquinone) Fe-S Protein 4 (Ndufs4) Gene
Dillon W Leong, Jasper C Komen, Chelsee A Hewitt, Estelle Arnaud, Matthew McKenzie, Belinda Phipson, Melanie Bahlo, Adrienne Laskowski, Sarah A Kinkel, Gayle M Davey, William R Heath, Anne K Voss, Rene P Zahedi, James J Pitt, Roman Chrast, Albert Sickmann, Michael T Ryan, Gordon K Smyth, David R Thorburn, Hamish S Scott
Journal of Biological Chemistry | AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC | Published : 2012
Awarded by National Health and Medical Research Council(NHMRC)
This work was supported by an Australian Postgraduate Award (to S.A.K.), National Health and Medical Research Council(NHMRC) fellowships (to H.H.S, D.R.T., G.K.S., and A.K.V.), NHMRC career development awards (to M.M. and M.B.), NHMRC Program Grant 257501, and NHMRC Project Grants 607403 and 602530, the Australian Research Council (to M.T.R.), the Victorian Government's Operational Infrastructure Support Program, and the Nossal Leadership Award from the Walter and Eliza Hall Institute of Medical Research (to H.S.S.).Efficient animal management and data collection were facilitated by the Walter and Eliza Hall Institute of Medical Research (WEHI) and Murdoch Childrens Research Institute animal technicians. Processing of histological samples was aided by WEHI Histology and the Integrative Neuroscience Facility. Affymetrix exon arrays and linkage genotyping were performed by the Australian Genome Research Facility, which was established through the Commonwealth-funded Major National Research Facilities Program.