Journal article
Modeling extracellular electrical stimulation: I. Derivation and interpretation of neurite equations
H Meffin, B Tahayori, DB Grayden, AN Burkitt
Journal of Neural Engineering | Published : 2012
Abstract
Neuroprosthetic devices, such as cochlear and retinal implants, work by directly stimulating neurons with extracellular electrodes. This is commonly modeled using the cable equation with an applied extracellular voltage. In this paper a framework for modeling extracellular electrical stimulation is presented. To this end, a cylindrical neurite with confined extracellular space in the subthreshold regime is modeled in three-dimensional space. Through cylindrical harmonic expansion of Laplace's equation, we derive the spatio-temporal equations governing different modes of stimulation, referred to as longitudinal and transverse modes, under types of boundary conditions. The longitudinal mode is..
View full abstractGrants
Awarded by Victorian Life Sciences Computation Initiative (VLSCI) on its Peak Computing Facility at the University of Melbourne, an initiative of the Victorian Government
Funding Acknowledgements
This research was supported by the Australian Research Council (ARC) through its Special Research Initiative (SRI) in Bionic Vision Science and Technology grant to Bionic Vision Australia (BVA). The Bionics Institute acknowledges the support it receives from the Victorian Government through its Operational Infrastructure Support Program. This research was supported by a Victorian Life Sciences Computation Initiative (VLSCI) grant number VR0138 on its Peak Computing Facility at the University of Melbourne, an initiative of the Victorian Government.