Journal article
Interleukin 28B polymorphisms are the only common genetic variants associated with low-density lipoprotein cholesterol (LDL-C) in genotype-1 chronic hepatitis C and determine the association between LDL-C and treatment response
PJ Clark, AJ Thompson, M Zhu, DM Vock, Q Zhu, D Ge, K Patel, SA Harrison, TJ Urban, S Naggie, J Fellay, HL Tillmann, K Shianna, S Noviello, LD Pedicone, R Esteban, P Kwo, MS Sulkowski, N Afdhal, JK Albrecht Show all
Journal of Viral Hepatitis | Published : 2012
Abstract
Low-density lipoprotein cholesterol (LDL-C) levels and interleukin 28B (IL28B) polymorphism are associated with sustained viral response (SVR) to peginterferon/ribavirin (pegIFN/RBV) for chronic hepatitis C (CHC) infection. IL28B has been linked with LDL-C levels using a candidate gene approach, but it is not known whether other genetic variants are associated with LDL-C, nor how these factors definitively affect SVR. We assessed genetic predictors of serum lipid and triglyceride levels in 1604 patients with genotype 1 (G1) chronic hepatitis C virus (HCV) infection by genome-wide association study and developed multivariable predictive models of SVR. IL28B polymorphisms were the only common ..
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Awarded by National Institutes of Health
Funding Acknowledgements
The study was funded by Schering-Plough Research Institute, Kenilworth, NJ (now Merck and Co.). Drs Clark and Thompson received funding support from the Duke Clinical Research Institute, the Richard Boebel Family Fund, the National Health and Medical Research Council of Australia (PJC: APP1017139) and the Gastroenterological Society of Australia. Dr Clark received funding from the National Centre in HIV Epidemiology and Clinical Research (now The Kirby Institute for Infection and Immunity in Society), University of New South Wales, Australia, and the AASLD/LIFER Clinical and Translational Research Fellowship in Liver Diseases Award. Dr Thompson received funding from the Royal Australian College of Physicians.