Journal article

Re-evaluating the biological significance of seminal vesicle invasion (SVI) in locally advanced prostate cancer

Nikhil Sapre, John Pedersen, Matthew K Hong, Laurence Harewood, Justin Peters, Anthony J Costello, Chris M Hovens, Niall M Corcoran



OBJECTIVE: • To examine the impact of seminal vesicle invasion (SVI) in patients with locally advanced (pT3) prostate cancer on clinical outcome. • To explore the clinical association of SVI with metastatic disease. • To distinguish between the possibilities that either seminal vesicles possess their own biological significance and represent a privileged staging site for systemic tumour cell dissemination, or that their invasion is a surrogate marker for an aggressive large-volume poorly differentiated cancer. PATIENTS AND METHODS: • Patients with extraprostatic extension (EPE) and/or SVI were identified from a prospectively recorded and maintained prostate cancer database. • Patients were c..

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