Journal article
Prostate tumour volume is an independentpredictor of early biochemical recurrence in a high risk radical prostatectomy subgroup Matthew
KH Hong, B Namdarian, NM Corcoran, J Pedersen, DG Murphy, JS Peters, L Harewood, N Sapre, K Rzetelski-West, AJ Costello, CM Hovens
Pathology | LIPPINCOTT WILLIAMS & WILKINS | Published : 2011
Abstract
Aims: To assess if accurately determined tumour volume variables could serve as independentpredictors of early biochemical recurrence in high riskprostate cancerpatients who underwent radical prostatectomy. Methods: Tumour volume variables were calculated by digitalplanimetry in 269prostatectomy specimens ofpatients with high riskprostate cancer. The associations to biochemical progression of tumour volume and clinicoPathological variables, including age,pre-operativeprostate specific antigen (PSA) levels, final Gleason score,Pathological T stage, and surgical margins, were examined using univariate and multivariate Coxproportional hazards analyses. Results: Median tumour volume was 3.7 ml [..
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Funding Acknowledgements
This work was supported by scholarships from the Royal Australasian College of Surgeons and the National Health and Medical Research Council. The work was funded through the Melbourne Urology Trust, Australian Urological Association, Cybec Trust, Prostate Cancer Foundation of Australia, Victorian Prostate Cancer Research Consortium and a federal grant for the Australian Prostate Cancer Research Centre at Epworth Hospital. We are also grateful to Dr Andrew Ryan, TissuPath Pty Ltd, for his assistance in preparing the manuscript.