Specific antibody-dependent cellular cytotoxicity responses associated with slow progression of HIV infection

LH Wren; AW Chung; G Isitman; AD Kelleher; MS Parsons; J Amin; DA Cooper; I Stratov; M Navis; SJ Kent

Journal article

Specific antibody-dependent cellular cytotoxicity responses associated with slow progression of HIV infection

LH Wren, AW Chung, G Isitman, AD Kelleher, MS Parsons, J Amin, DA Cooper, I Stratov, M Navis, SJ Kent

Immunology | Published : 2013

DOI: 10.1111/imm.12016

Abstract

Antibody-dependent cellular cytotoxicity (ADCC) is potentially an effective adaptive immune response to HIV infection. However, little is understood about the role of ADCC in controlling chronic infection in the small number of long-term slow-progressors (LTSP) who maintain a relatively normal immunological state for prolonged periods of time. We analysed HIV-specific ADCC responses in sera from 139 HIV+ subjects not on antiretroviral therapy. Sixty-five subjects were LTSP, who maintained a CD4 T-cell count > 500/μl for over 8 years after infection without antiretroviral therapy and 74 were non-LTSP individuals. The ADCC responses were measured using an natural killer cell activation assay t..

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University of Melbourne Researchers

Amy Chung Author

Stephen Kent Author

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Grants

Awarded by National Institute of Allergy and Infectious Diseases

Funding Acknowledgements

The Antibody-Dependent Cellular Cytotoxicity study collaboration group includes physician and nurses who helped to recruit subjects for the study: T. Read, M. Chen, C. Fairley, T. Schmidt, C. Bradshaw, R. Moore, K. Fethers, J. Silvers and H. Kent from the Melbourne Sexual Health Centre; R. McFarlane, D. Baker, M. McMurchie, East Sydney Doctors; S. Pett, A. Carr, St Vincent's Hospital Sydney; R. Finlayson, Taylor Square Clinic; Don Smith, Albion St Centre; T. M. Soo, Interchange General Practice Canberra; M. Kelly, J. Patten, AIDS Medical Centre Brisbane; B. Anderson, St Leonard's Medical Centre; S. Marlton, Port Kembla Sexual Health Clinic; D. Smith, Lismore Sexual Health; M. Bloch, Holdsworth House General Practice; N. Doong, Dr Doong's Surgery; N. Roth, Prahran Market Clinic and A. Shaik for the curation of the database. We are grateful to all the individuals who participated in the study for their assistance. This work was financially supported by NHMRC awards 510448 and 455350, ARC award LP0991498, the Australian Centre for HIV and Hepatitis Virology Research, The Royal Australasian College of Physicians, The Ramaciotti Foundation, and National Institutes of Health award R21AI081541.