Journal article

Differential Diagnosis in Alzheimer's Disease and Dementia with Lewy Bodies via VMAT2 and Amyloid Imaging

Victor L Villemagne, Nobuyuki Okamura, Svetlana Pejoska, John Drago, Rachel S Mulligan, Gael Chetelat, Graeme O'Keefe, Gareth Jones, Hank F Kung, Michael Pontecorvo, Colin L Masters, Daniel M Skovronsky, Christopher C Rowe



BACKGROUND: The noninvasive evaluation of nigrostriatal dopaminergic integrity by PET can provide useful information for the differential diagnosis between dementia with Lewy bodies (DLB) and Alzheimer's disease (AD). OBJECTIVES: To evaluate the diagnostic potential of imaging striatal monoaminergic terminal integrity with the novel vesicular monoamine transporter type 2 (VMAT2) radioligand [(18)F]AV-133 and PET to distinguish DLB from AD. METHODS: Fifty participants [9 DLB, 11 AD, 20 Parkinson's disease (PD) and 10 healthy age-matched control subjects (HC)] underwent [(18)F]AV-133 PET studies. Additionally, 20 participants underwent amyloid imaging PET scans with either [(11)C]PiB or (18)F-..

View full abstract