Journal article
Differential diagnosis in Alzheimer's disease and dementia with Lewy bodies via VMAT2 and amyloid imaging
VL Villemagne, N Okamura, S Pejoska, J Drago, RS Mulligan, G Chételat, G O'Keefe, G Jones, HF Kung, M Pontecorvo, CL Masters, DM Skovronsky, CC Rowe
Neurodegenerative Diseases | Published : 2012
DOI: 10.1159/000334535
Abstract
Background: The noninvasive evaluation of nigrostriatal dopaminergic integrity by PET can provide useful information for the differential diagnosis between dementia with Lewy bodies (DLB) and Alzheimer's disease (AD). Objectives: To evaluate the diagnostic potential of imaging striatal monoaminergic terminal integrity with the novel vesicular monoamine transporter type 2 (VMAT2) radioligand [ 18F]AV-133 and PET to distinguish DLB from AD. Methods: Fifty participants [9 DLB, 11 AD, 20 Parkinson's disease (PD) and 10 healthy age-matched control subjects (HC)] underwent [ 18F]AV-133 PET studies. Additionally, 20 participants underwent amyloid imaging PET scans with either [ 11C]PiB or 18F-florb..
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Awarded by Japan Society for the Promotion of Science