Automated 11C-PiB Standardized Uptake Value Ratio

Abstract

Rationale and Objectives: Radiotracers such as 11C-PiB have enabled the in vivo imaging of amyloid-β plaques in the brain, one of the histopathologic hallmarks of Alzheimer's disease (AD). Standardized uptake value ratio (SUVR) has become the most common normalization for 11C-PiB as it does not require dynamic scans or blood sampling. Normalization is performed by computing the ratio of 11C-PiB retention in the whole brain to that in cerebellar gray matter. However, SUVR is still conducted manually and is time consuming. An automated normalization algorithm is proposed. Materials and Methods: Sixty participants from the Australian Imaging Biomarkers and Lifestyle (AIBL) study were used to te..