Journal article

A beta deposits in older non-demented individuals with cognitive decline are indicative of preclinical Alzheimer's disease

VL Villemagne, KE Pike, D Darby, P Maruff, G Savage, S Ng, U Ackermann, TF Cowie, J Currie, SG Chan, G Jones, H Tochon-Danguy, G O'Keefe, CL Masters, CC Rowe

Neuropsychologia | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2008

Abstract

Approximately 30% of healthy persons aged over 75 years show Abeta deposition at autopsy. It is postulated that this represents preclinical Alzheimer's disease (AD). We evaluated the relationship between Abeta burden as assessed by PiB PET and cognitive decline in a well-characterized, non-demented, elderly cohort. PiB PET studies and cognitive tests were performed on 34 elderly participants (age 73+/-6) from the longitudinal Melbourne Healthy Aging Study (MHAS). Subjects were classified as being cognitively 'stable' or 'declining' by an independent behavioural neurologist based on clinical assessment and serial word-list recall scores from the preceding 6-10 years. Decline was calculated fr..

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