Triheptanoin reduces seizure susceptibility in a syndrome-specific mouse model of generalized epilepsy

Tae Hwan Kim; Karin Borges; Steven Petrou; Christopher A Reid

Journal article

Triheptanoin reduces seizure susceptibility in a syndrome-specific mouse model of generalized epilepsy

Tae Hwan Kim, Karin Borges, Steven Petrou, Christopher A Reid

EPILEPSY RESEARCH | ELSEVIER | Published : 2013

DOI: 10.1016/j.eplepsyres.2012.09.016

Abstract

Triheptanoin is a triglyceride containing heptanoate, an odd-chained medium fatty acid that is metabolized to produce propionyl-CoA and subsequently C4 intermediates of the citric acid cycle and therefore capable of anaplerosis. These metabolic products are believed to underlie triheptanoin's anticonvulsant effects in rodent seizure models. Here we investigate the anticonvulsive effects of oral triheptanoin in a syndrome-specific genetic mouse model of generalized epilepsy based on the GABA(A)γ2(R43Q) mutation. Mice were fed a diet supplemented with triheptanoin from weaning for three weeks prior to electrocortical recordings. Occurrence and durations of spike and wave discharges (SWDs) were..

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University of Melbourne Researchers

Steven Petrou Author Florey Department of Neuroscience and Mental Health

Christopher Reid Author Medicine - Austin Health

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Grants

Awarded by National Health and Medical Research Council of Australia

Awarded by Australian Research Council

Funding Acknowledgements

This study was supported by the National Health and Medical Research Council of Australia (Grant numbers 400121, 628520 and 631541). CAR was also supported by an Australian Future Fellowship, Australian Research Council (#FT0990628). SP was supported by a NHMRC fellowship. The Florey Neuroscience Institutes are supported by Victorian State Government Infrastructure Funds.