Triheptanoin reduces seizure susceptibility in a syndrome-specific mouse model of generalized epilepsy
Tae Hwan Kim, Karin Borges, Steven Petrou, Christopher A Reid
EPILEPSY RESEARCH | ELSEVIER | Published : 2013
Triheptanoin is a triglyceride containing heptanoate, an odd-chained medium fatty acid that is metabolized to produce propionyl-CoA and subsequently C4 intermediates of the citric acid cycle and therefore capable of anaplerosis. These metabolic products are believed to underlie triheptanoin's anticonvulsant effects in rodent seizure models. Here we investigate the anticonvulsive effects of oral triheptanoin in a syndrome-specific genetic mouse model of generalized epilepsy based on the GABA(A)γ2(R43Q) mutation. Mice were fed a diet supplemented with triheptanoin from weaning for three weeks prior to electrocortical recordings. Occurrence and durations of spike and wave discharges (SWDs) were..View full abstract
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Awarded by National Health and Medical Research Council of Australia
Awarded by Australian Research Council
This study was supported by the National Health and Medical Research Council of Australia (Grant numbers 400121, 628520 and 631541). CAR was also supported by an Australian Future Fellowship, Australian Research Council (#FT0990628). SP was supported by a NHMRC fellowship. The Florey Neuroscience Institutes are supported by Victorian State Government Infrastructure Funds.